VITAMIN D


VITAMIN D Other names: Calciferol

  • 1,25-dihyroxy vitamin D (calcitriol)
  • Animal version: Vitamin D3 or Cholecalciferol
  • Plant version: Vitamin D2 or Ergocalciferol
  • Precursor is the body’s own cholesterol

THE SUNSHINE VITAMIN

  • Helps Calcium form strong bones
  • Helps regulate blood calcium levels
  • Approximately 90% its requirement obtained from sun
  • UV light from sun hits skin, triggers synthesis
  • Activated in liver and kidneys 
VITAMIN D – THE SUNSHINE VITAMIN

SOURCES

  • Fortified
    • Milk
    • Margarine
    • Butter
    • Cereal
  • Veal, Beef
  • Egg yolk
  • Fatty fish (Salmon, Sardines, Herring)

RDA

Adequate Intake (AI)

19-50 years: 5 μg/day

51-70 years: 10 μg/day

More than 70 years: 15 μg/day

Upper level for adults: 50 μg/day

BIOCHEMICAL FUNCTIONS

  • Chief functions in the body

. Mineralization of bones

i. Raises blood calcium and phosphorus by increasing absorption from digestive tract

ii. Withdrawing calcium from bones

iii. Stimulating retention by kidneys

  • Calcium and phosphorous absorption

i. Without D only 10-15% dietary          calcium absorbed

ii. With D absorption increased to               30-40%

iii. Without D about 60% phosphorous       absorbed

iv. With D absorption increased to ~80%

  • Recent research indicates Vitamin D has a role in the prevention of
    Heart disease
    Type-1 Diabetes
    Multiple Sclerosis
    Rheumatoid Arthritis
    Crohn’s Disease
    Certain Cancers
  • Nonskeletal functions of Vitamin D
    • Brain Prostate Breast Colon Tissues and Immune Cells 
    • Have Vitamin D receptors and respond to 1,25- dihydroxyvitamin D (the active form of D)
    • 1,25-dihydroxyvitamin D controls more than 200 genes
    • Potent Immunomodulator

DEFICIENCY

  • Rickets

Inadequate calcification

Misshapen, deformed

Lax muscles with spasm

  • Osteomalacia

Loss of calcium

Soft, deformed bones

Pain, weakness

TOXICITY

  • Toxicity – Hypervitaminosis D
    • Elevated blood calcium
    • Calcification of soft tissues (blood vessels, kidneys, heart, lungs, tissues around joints)
  • Thought to be the most frequently occurring vitamin toxicity

EXCESS

  • Can be poisonous
  • Toxicity occurs from consuming too many supplements
  • Raises blood calcium levels and the excess is absorbed into the kidneys and other soft organs

Other Biochemistry Notes :-

Biochemistry of Proteins

Carbohydrate Metabolism

VITAMIN PYRIDOXINE AND BIOTIN

Pyrimidine metabolism

Purine Metabolism

Cardiac Biomarkers

. Blood Metabolism (Heme synthesis and breakdown)

Haemoglobinopathies

DNA Repair

Regulation of gene expression

DNA Replication

Transcription

Protein synthesis and genetic code

Detoxification (Xenobiotics)

Liver Function Test

Transamination Deamination & Urea Cycle

METABOLISM OF INDIVIDUAL AMINO ACIDS

Hydroxy amino acids

ACIDIC AMINO ACIDS (Aspartate and Glutamate)

Inborn Error Of Phenyl alanine, Tyrosine Metabolism

Electron Transport Chain & Biological Oxidation

RENAL FUNCTION TEST

Biochemistry Of Sodium, Potassium & Chloride

Congenital Kidney Diseases

Glucose Estimation

Cancer

Triacylglycerol And Adipose tissue Metabolism

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