VITAMIN D


VITAMIN D Other names: Calciferol

  • 1,25-dihyroxy vitamin D (calcitriol)
  • Animal version: Vitamin D3 or Cholecalciferol
  • Plant version: Vitamin D2 or Ergocalciferol
  • Precursor is the body’s own cholesterol

THE SUNSHINE VITAMIN

  • Helps Calcium form strong bones
  • Helps regulate blood calcium levels
  • Approximately 90% its requirement obtained from sun
  • UV light from sun hits skin, triggers synthesis
  • Activated in liver and kidneys 
VITAMIN D – THE SUNSHINE VITAMIN

SOURCES

  • Fortified
    • Milk
    • Margarine
    • Butter
    • Cereal
  • Veal, Beef
  • Egg yolk
  • Fatty fish (Salmon, Sardines, Herring)

RDA

Adequate Intake (AI)

19-50 years: 5 μg/day

51-70 years: 10 μg/day

More than 70 years: 15 μg/day

Upper level for adults: 50 μg/day

BIOCHEMICAL FUNCTIONS

  • Chief functions in the body

. Mineralization of bones

i. Raises blood calcium and phosphorus by increasing absorption from digestive tract

ii. Withdrawing calcium from bones

iii. Stimulating retention by kidneys

  • Calcium and phosphorous absorption

i. Without D only 10-15% dietary          calcium absorbed

ii. With D absorption increased to               30-40%

iii. Without D about 60% phosphorous       absorbed

iv. With D absorption increased to ~80%

  • Recent research indicates Vitamin D has a role in the prevention of
    Heart disease
    Type-1 Diabetes
    Multiple Sclerosis
    Rheumatoid Arthritis
    Crohn’s Disease
    Certain Cancers
  • Nonskeletal functions of Vitamin D
    • Brain Prostate Breast Colon Tissues and Immune Cells 
    • Have Vitamin D receptors and respond to 1,25- dihydroxyvitamin D (the active form of D)
    • 1,25-dihydroxyvitamin D controls more than 200 genes
    • Potent Immunomodulator

DEFICIENCY

  • Rickets

Inadequate calcification

Misshapen, deformed

Lax muscles with spasm

  • Osteomalacia

Loss of calcium

Soft, deformed bones

Pain, weakness

TOXICITY

  • Toxicity – Hypervitaminosis D
    • Elevated blood calcium
    • Calcification of soft tissues (blood vessels, kidneys, heart, lungs, tissues around joints)
  • Thought to be the most frequently occurring vitamin toxicity

EXCESS

  • Can be poisonous
  • Toxicity occurs from consuming too many supplements
  • Raises blood calcium levels and the excess is absorbed into the kidneys and other soft organs

Other Biochemistry Notes :-

Biochemistry of Proteins

Carbohydrate Metabolism

VITAMIN PYRIDOXINE AND BIOTIN

Pyrimidine metabolism

Purine Metabolism

Cardiac Biomarkers

. Blood Metabolism (Heme synthesis and breakdown)

Haemoglobinopathies

DNA Repair

Regulation of gene expression

DNA Replication

Transcription

Protein synthesis and genetic code

Detoxification (Xenobiotics)

Liver Function Test

Transamination Deamination & Urea Cycle

METABOLISM OF INDIVIDUAL AMINO ACIDS

Hydroxy amino acids

ACIDIC AMINO ACIDS (Aspartate and Glutamate)

Inborn Error Of Phenyl alanine, Tyrosine Metabolism

Electron Transport Chain & Biological Oxidation

RENAL FUNCTION TEST

Biochemistry Of Sodium, Potassium & Chloride

Congenital Kidney Diseases

Glucose Estimation

Cancer

Triacylglycerol And Adipose tissue Metabolism

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  232. Helpful Nourishment Recommendations Many pieces of your life beyond your diet plan are impacted by nutrition. To possess outstanding diet, nevertheless, it could at times truly feel out of the question. This article has guidance on how to come to be more healthy. It is very important eat top quality healthy proteins everyday. Healthy proteins help build muscle groups and also in maintaining healthy skin. In addition they aid in your energy metabolism and cellular operations. Health proteins likewise helps your body control harmful diseases. Some healthy food that have an exceptional level of health proteins are fowl, seafood and legumes and fowl. Get correct amounts of supplement B12 to build red-colored blood vessels cells. Vegans and senior citizens are frequently lacking with this using their diet programs. People who have anemia also at an increased risk. You can take a nutritional supplement or consume cereal. On the other hand, seek out this nutrient in breakfast time cereals. Fiber content is an important in everyone’s diet program. Dietary fiber is great for bodyweight and retaining you against sensation hungry. Additionally, it allow you to decrease blood vessels cholestrerol levels levels. Fiber content may also decrease the potential risk of cancers and diabetes mellitus at the same time. Cease taking in foods while you are virtually complete. This will stop you from unnecessary eating and permit your body to know when you ought to begin digestion. Make best use of your caloric allowance by eating sensible food to gasoline your system. Your whole body will answer more favorably to 1800 energy of toned meat, like slim meat and protein, then this same unhealthy calories in fried potatoes and soft drinks burst. The type of what you eat issues equally as critical as the amount consume. Walnuts are probably the most beneficial nuts to work with in made meals. Raise protein degrees, and help you have a healthier blood vessels cell matter, these are the basic most healthy amongst other almonds due to their power to reduce cholesterol levels. Additionally, they are generally less costly than various other nut versions. In the event you replacement floor poultry for floor beef, you are able to know numerous health advantages, even though a lot of people aren’t too fond of ground turkey’s dryness. You can include essential olive oil and sliced red onion to further improve the taste and make your turkey a lot more drinks. Your meat will probably be less body fat and have wonderful flavor. Improving the meals that you devote your body could work wonders for your personal frame of mind. Regardless of how aged you might be, the tips you’ve just read may be used to increase your life. Safeguard the entire body you might have due to the fact it’s the only one you will ever have.

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  238. The younger you are when you begin marijuana use and the more often and longer you use it, the more likely it will impact your brain. Your brain does not stop developing until around 25 years of age. If you are pregnant or breastfeeding, you should not use marijuana, it poses a risk to the fetus or newborn child. Heavy marijuana use has been linked to lower birth weight and exposure to THC (or “tetrahydrocannabinol” – the chemical responsible for most of the psychological effects) can affect a baby’s brain development. While the research so far is inconclusive there are some other findings of the effects of THC on babies. If you are a mother who used marijuana during pregnancy, your child could have:

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  240. Keep Lean And Healthier Effortlessly Using This Clever Nutrition Plan Nutrition is really a fundamental part of our everyday life. We make a choice to consume wholesome or perhaps to act otherwise. This article has some terrific methods that you can eat good food and never have to starve yourself. Food items which were highly processed do not lend to fat loss will be the objective. The content label must include popular elements listed ought not to be terms that folks fully grasp. Steer clear of those things who have lots of substances you may not acknowledge. Rather than giving up favorite meals that aren’t healthier, choose wholesome options which are related in design and feel. You want to understand how a variety of selections effect your food selections.It has become easier through the years as much eating places now that many eateries offer you this information. Make best use of your everyday calories allowance to acquire several vitamins and minerals into the body. It is better for you to take in 1,8000 calorie consumption worth of nutritious grain, grain, and protein compared to the exact same calorie allotment of fast food. The sum you consume is as crucial as being the quantity you actually eat. Take the time to encounter your food in a dash. Chew quite slowly and enjoy each and every chew. Carrying out this will help are full easier. Additionally, you will not usually eat way too much when you decelerate and revel in your dish. Include inulin in your diet plan wholesome. Food products like garlic herb, leeks and artichokes.This carbo can boost your digestive system when helping you shed weight. Garlic also improve your immune system. Corn syrup is recognized as a type of sweets utilized to sweeten numerous items and you should stay away from these products when attempting to lose weight. Applying this system may help you steer clear of going out to eat an issue that is harmful. Possessing a very good selection inside your dish options prevents from becoming getting to and bored for some thing bad. People with diabetes needs to be cautious because alcohol can reduced blood sugar levels to plummet. Ideally, can use the information that you simply examined to boost your standard of living. We hope you’re much more knowledgeable about nutrition if you didn’t know significantly before. The following tips must be placed on your way of life everyday.

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